CJC-1295 DAC is the long-acting version of CJC-1295: the same modified fragment of growth hormone releasing hormone, with a drug affinity complex attached that binds albumin in the bloodstream. That one addition stretches its half-life from hours to roughly a week, and it is the reason CJC 1295 DAC and CJC 1295 No DAC are studied as two different research tools rather than two strengths of one.

You will see it written CJC-1295 DAC, CJC 1295 DAC, CJC 1295 with DAC and long-acting CJC-1295. This guide covers what the DAC does, how the albumin binding works, how it compares with No DAC, what the research does and does not show, and reconstitution tables for both vial sizes. CJC-1295 DAC is supplied by PhaseOne in 5mg and 10mg vials, strictly for laboratory research.

On this page

What is CJC-1295 DAC | What the DAC does | DAC vs No DAC | The research | Reconstitution | Checking purity | FAQs

Key points at a glance

• The modified 29 amino acid GHRH fragment with a drug affinity complex attached through an added lysine
• Written CJC-1295 DAC, CJC 1295 DAC, CJC 1295 with DAC and long-acting CJC-1295
• The DAC binds albumin, which shields the peptide from clearance
• Half-life of roughly six to eight days in published early human research, against hours for No DAC
• Gives sustained GHRH receptor activation rather than the pulsatile pattern of No DAC
• Not interchangeable with No DAC: findings on one do not transfer to the other
• Research base is limited, with no approved medicine built on it
• Supplied in 5mg and 10mg vials for laboratory research only

What is CJC-1295 DAC?

Native growth hormone releasing hormone is broken down by the enzyme DPP-4 within minutes. CJC-1295 starts from the first 29 amino acids of that hormone and swaps four of them at the points where the enzyme cuts, so the fragment survives long enough to study. That modified fragment on its own is CJC-1295 No DAC , also called Mod GRF 1-29.

CJC-1295 DAC goes one step further. An extra lysine is added to the end of the chain, carrying a reactive group known as the drug affinity complex. The receptor-binding part of the molecule is unchanged; what changes is how long it stays in circulation.

What the drug affinity complex does

The drug affinity complex is a reactive group that forms a bond with albumin, the most abundant protein in blood. Albumin circulates for weeks, so a peptide attached to it is carried along and shielded from the kidney filtration and enzyme activity that would otherwise clear it.

The practical result is a molecule that keeps signalling at the GHRH receptor for days after a single administration. That is useful where a study needs a steady background signal, and a drawback where it needs the on-off pattern of natural GHRH release.

CJC-1295 DAC vs No DAC

This is the distinction that matters most, and the one most often blurred in listings and forums. Both versions act at the same receptor; the difference is duration, and duration changes the research question.

Because the older literature sometimes used CJC-1295 on its own to mean the DAC version, a finding quoted for CJC-1295 needs checking against the molecule actually studied. For the No DAC side and the general background on the compound, see the CJC-1295 guide .

What the research shows, and what it does not

CJC-1295 DAC is one of the few research peptides with published early human pharmacokinetic data. That work reported a half-life of roughly six to eight days, with growth hormone and IGF-1 levels staying raised for several days after a single administration.

The limits are just as important. The compound was not taken forward to an approved medicine, so there is no long-term human outcome data and no regulator has assessed it for any use. Sustained activation is also a different exposure from the pulsatile signalling the body produces naturally, which is exactly why the No DAC form exists. And findings on CJC-1295 DAC cannot be read across to No DAC, or the other way round.

Reconstituting 5mg and 10mg CJC-1295 DAC vials

CJC-1295 DAC arrives as a lyophilised powder and is reconstituted with bacteriostatic water . The tables below show the concentration each volume gives and how much peptide each unit holds on a 100 unit U-100 syringe.

Work out any other combination with the peptide dosage calculator . Add the water slowly down the vial wall, swirl rather than shake, then refrigerate and keep it out of light. The reconstitution guide and storage guide cover technique and stability in full.

Checking purity and identity

With CJC-1295 the identity result on a certificate matters as much as the purity figure, because DAC and No DAC are sold under overlapping names and are different molecules. A purity result tells you how much of the vial is peptide; identity tells you which peptide it is.

Every PhaseOne batch is independently tested to a standard of at least 99% purity by HPLC, and the certificate for each batch is published in our public COA library . No COA is shipped with the vial; it is simply public, so you can read the result before ordering. For how to read a chromatogram, see the HPLC testing guide .

Buying CJC-1295 DAC in Australia

PhaseOne supplies CJC-1295 DAC in 5mg and 10mg vials from Australian stock, shipped Australia-wide, for laboratory research only, with every batch HPLC tested to at least 99% purity and the certificate published publicly.

Three checks against any Australian supplier. Does the listing say DAC explicitly, rather than just CJC-1295? Is the certificate batch-specific rather than a generic sample? And is the stock held locally, which affects both transit time and the cold chain? Researchers who need the pulsatile form instead should look at CJC-1295 No DAC or the CJC-1295 and Ipamorelin blend .

Related research guides

For the No DAC form and the compound in general, see the CJC-1295 guide . For the pairing, the CJC-1295 and Ipamorelin guide . For the same receptor, the Tesamorelin guide . For the category, the growth hormone peptide guide .

Frequently Asked Questions

What is CJC-1295 DAC?

The modified 29 amino acid GHRH fragment known as CJC-1295, with a drug affinity complex attached through an added lysine. The DAC binds albumin, which keeps the molecule in circulation for days rather than hours.

What does DAC stand for?

Drug affinity complex. It is a reactive group that bonds to albumin in the blood, shielding the attached peptide from clearance.

Is CJC 1295 with DAC the same as CJC-1295 DAC?

Yes. CJC 1295 with DAC, CJC-1295 DAC, CJC 1295 DAC and long-acting CJC-1295 all describe the same molecule.

What is the difference between CJC-1295 DAC and No DAC?

Duration. The DAC version binds albumin and lasts roughly a week, giving sustained receptor activation. No DAC lasts hours and gives a pulsatile pattern closer to natural signalling. They are different molecules and findings do not transfer between them.

How long does CJC-1295 DAC last?

Published early human research reported a half-life of roughly six to eight days, with growth hormone and IGF-1 levels raised for several days after a single administration.

Is CJC-1295 DAC studied with Ipamorelin?

Less often than No DAC. The No DAC form is the usual partner because its short window can be timed alongside Ipamorelin, while the DAC version gives a continuous signal.

What vial sizes does CJC-1295 DAC come in?

PhaseOne supplies 5mg and 10mg vials of lyophilised powder. Reconstitution tables for both are above.

How should CJC-1295 DAC be stored?

Lyophilised vials refrigerated and out of light. Once reconstituted, refrigerate immediately, keep it dark, and prepare only what the work needs.

What purity is PhaseOne CJC-1295 DAC?

At least 99% by independent HPLC testing, with the certificate for each batch published in our public COA library. No COA is shipped with the vial.

Is CJC-1295 DAC approved in Australia?

No. It is not registered on the ARTG and is not approved for supply as a medicine, so no pharmacy or chemist stocks it. It is supplied through research suppliers for laboratory research only.

Where can I buy CJC-1295 DAC in Australia?

PhaseOne supplies CJC-1295 DAC in 5mg and 10mg vials from Australian stock, shipped Australia-wide, for laboratory research only, with batch-specific HPLC certificates published publicly.

Disclaimer

All products supplied by PhaseOne are intended strictly for laboratory research purposes only. Products are not intended for human consumption, therapeutic use, cosmetic use, veterinary use, or diagnostic applications.